Literature summary for 3.4.22.B30 extracted from

Hatta, T.; Iemura, S.I.; Ohishi, T.; Nakayama, H.; Seimiya, H.; Yasuda, T.; Iizuka, K.; Fukuda, M.; Takeda, J.; Natsume, T.; Horikawa, Y.
Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B (2018), Sci. Rep., 8, 16756 .

Search for more literature for 3.4.22.B30

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microtubule	Calpain-10 processes microtubule associated protein 1 (MAP1) family proteins into heavy and light chains and regulates their binding activities to microtubules and actin filaments	Mus musculus	5874	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9ESK3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	in Capn10-/- mouse embryonic fibroblasts, MAP1B is localized at actin filaments rather than at microtubules	Mus musculus	-
pancreas	in pancreatic islets from Calpain-10 knockout mice, insulin secretion is significantly increased both at the high and low glucose levels	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CAPN10	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	Calpain-10 processes microtubule associated protein 1 (MAP1) family proteins into heavy and light chains and regulates their binding activities to microtubules and actin filaments. In Capn10-/- mouse embryonic fibroblasts, MAP1B is localized at actin filaments rather than at microtubules. Calpain-10 regulates actin dynamics via MAP1B cleavage. In pancreatic islets from Calpain-10 knockout mice, insulin secretion is significantly increased both at the high and low glucose levels	Mus musculus

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Release 2023.1 (January 2023)