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BRENDA support

Literature summary for 3.4.22.B30 extracted from

  • Cheverud, J.M.; Fawcett, G.L.; Jarvis, J.P.; Norgard, E.A.; Pavlicev, M.; Pletscher, L.S.; Polonsky, K.S.; Ye, H.; Bell, G.I.; Semenkovich, C.F.
    Calpain-10 is a component of the obesity-related quantitative trait locus Adip1 (2010), J. Lipid Res., 51, 907-913.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus
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strains SM/J and LG/J
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Synonyms

Synonyms Comment Organism
calpain-10
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Mus musculus
CAPN10
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Mus musculus

General Information

General Information Comment Organism
malfunction CAPN10 deficiency results in heavier weights and higher serum levels in LG/J crosses but not in SM/J crosses, CAPN10 deficiency results in lower glucose levels in crosses with SM/J but not in LG/J crosses Mus musculus
malfunction single or multiple molecular differences in or near the Capn10 locus are responsible for obesity- and diabetes-related differences between LG/J and SM/J inbred mouse strains Mus musculus
physiological function Capn10 plays an important role in regulating obesity and diabetes in mice Mus musculus