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Literature summary for 3.4.22.B30 extracted from
- Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells (2005), Mol. Endocrinol., 19, 213-224.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucose | gradual increase after 3.5 days of exposure | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | calpain-10 is the first diabetes gene that can be identified through a genome scan | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in INS-1 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| E64 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
immuno-stained bands at 26000, 54000 and 72000 Da between cytosol and membranes, SDS-PAGE, the 54000 Da isoform is associated with a synaptosomal-associated protein of 25000 Da | Homo sapiens |
| 64000 | - |
in the cytosol, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9HC96 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Homo sapiens | - |
| pancreatic islet | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain-10 | - |
Homo sapiens |
| CAPN10 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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