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Literature summary for 3.4.22.B28 extracted from
- Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP (2006), J. Biol. Chem., 281, 11214-11224.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpain inhibitor I | 0.010 mM | Mus musculus | |
| calpeptin | 0.010 mM | Mus musculus | |
| E64c | 0.050 mM | Mus musculus | |
| MG132 | 0.010 mM | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | mucous cells | Mus musculus | 9986 | - |
| cell surface | mucous cells | Rattus norvegicus | 9986 | - |
| Golgi apparatus | COS7 cells | Mus musculus | 5794 | - |
| Golgi apparatus | COS7 cells | Rattus norvegicus | 5794 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein from Escherichia coli | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| duodenum | - |
Mus musculus | - |
| duodenum | - |
Rattus norvegicus | - |
| gastric mucosa | in the gastric epithelium | Mus musculus | - |
| gastric mucosa | in the gastric epithelium | Rattus norvegicus | - |
| intestinal mucosa | mucous-secreting goblet cell in the duodenum | Rattus norvegicus | - |
| intestinal mucosa | mucus-secreting goblet cell in the duodenum | Mus musculus | - |
| stomach | - |
Mus musculus | - |
| stomach | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-subunit of the coat protein + H2O | 30°C, 5 mM Ca2+ | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | two-hybrid assay | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain | - |
Mus musculus |
| calpain | - |
Rattus norvegicus |
| calpain-8a | - |
Mus musculus |
| calpain-8a | - |
Rattus norvegicus |
| nCL-2 | - |
Mus musculus |
| nCL-2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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