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Literature summary for 3.4.22.B24 extracted from

  • Kashiwagi, A.; Schipani, E.; Fein, M.; Greer, P.; Shimada, M.
    Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation (2010), Mol. Cell. Biol., 30, 2799-2810.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B24

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclin D + H2O Mus musculus
-
 ?
-
 ?
p21Cip1 + H2O Mus musculus
-
 ?
-
 ?
p27Kip1 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ATDC-5 cell
-
 Mus musculus
-
chondrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclin D + H2O
-
 Mus musculus ?
-
 ?
p21Cip1 + H2O
-
 Mus musculus ?
-
 ?
p27Kip1 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain small subunit
-
 Mus musculus
Capn4
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deletion of calpain 4 leads to reduced chondrocyte proliferation and differentiation in embryonic growth plates. Deletion of calpain 4 in cells of the chondrocyte lineage correlated with impaired cell cycle progression at the G1/S transition, reduced cyclin D gene transcription Mus musculus
physiological function calpain 4 is essential for proper chondrocyte functions in embryonic growth plates Mus musculus