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Literature summary for 3.4.22.B19 extracted from
- YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection (2010), Infect. Immun., 78, 2329-2341.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Yersinia pseudotuberculosis | - |
serogroup O:1 strain 32777 (previously known as IP2777) | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Yersinia outer protein J | - |
Yersinia pseudotuberculosis |
| YopJ | - |
Yersinia pseudotuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | YopJ kills macrophages and dendritic cells, reduces their production of tumor necrosis factor alpha and interleukin-12, and promotes systemic colonization in mouse models of intestinal Yersinia infection. YopJ-promoted cytotoxicity and systemic colonization are associated with significant increases in neutrophils in spleens and the proinflammatory cytokines interleukin-18 and gamma interferon in serum samples of mice vaccinated with Yersinia pseudotuberculosis. A proinflammatory, rather than anti-inflammatory, process accompanies YopJ-promoted cytotoxicity leading to increased systemic colonization by Yersinia pseudotuberculosis and potentially enhancing adaptive immunity to a live vaccine | Yersinia pseudotuberculosis |
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