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Literature summary for 3.4.22.B19 extracted from

  • Sweet, C.R.; Conlon, J.; Golenbock, D.T.; Goguen, J.; Silverman, N.
    YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction (2007), Cell. Microbiol., 9, 2700-2715.
    View publication on PubMed
Search for more literature for 3.4.22.B19

Cloned(Commentary)

Cloned (Comment) Organism
-
 Yersinia pestis

Protein Variants

Protein Variants Comment Organism
C172A no deubiquitination activity Yersinia pestis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
TRAF3-ubiquitin + H2O Yersinia pestis YopJ is a deubiquitinating protease that acts on TRAF proteins to prevent or remove the K63-polymerized ubiquitin conjugates required for signal transduction TRAF3 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O Yersinia pestis YopJ is a deubiquitinating protease that acts on TRAF proteins to prevent or remove the K63-polymerized ubiquitin conjugates required for signal transduction TRAF6 + ubiquitin
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia pestis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
TRAF3-ubiquitin + H2O
-
 Yersinia pestis TRAF3 + ubiquitin
-
 ?
TRAF3-ubiquitin + H2O YopJ is a deubiquitinating protease that acts on TRAF proteins to prevent or remove the K63-polymerized ubiquitin conjugates required for signal transduction Yersinia pestis TRAF3 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O
-
 Yersinia pestis TRAF6 + ubiquitin
-
 ?
TRAF6-ubiquitin + H2O YopJ is a deubiquitinating protease that acts on TRAF proteins to prevent or remove the K63-polymerized ubiquitin conjugates required for signal transduction Yersinia pestis TRAF6 + ubiquitin
-
 ?

Synonyms

Synonyms Comment Organism
YopJ
-
 Yersinia pestis