Literature summary for 3.4.22.B19 extracted from

Monnazzi, L.G.; Carlos, I.Z.; de Medeiros, B.M.
Influence of Yersinia pseudotuberculosis outer proteins (Yops) on interleukin-12, tumor necrosis factor alpha and nitric oxide production by peritoneal macrophages (2004), Immunol. Lett., 94, 91-98.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Yersinia pseudotuberculosis	mice infected with wild-type strain of Yersinia pseudotuberculosis show the highest TNF-alpha production on the 21st day after infection in the culture supernatant of cells incubated with LPS. During the infection with mutant strains unable to secrete YopJ, there is no TNF-alpha production on both the 7th and 28th days after infection, but the production is increased on the 21st day with the cells incubated with LPS and HKY (2.1fold higher than the control group)	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Yersinia pseudotuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mice infected with wild-type strain of Yersinia pseudotuberculosis show the highest TNF-alpha production on the 21st day after infection in the culture supernatant of cells incubated with LPS. During the infection with mutant strains unable to secrete YopJ, there is no TNF-alpha production on both the 7th and 28th days after infection, but the production is increased on the 21st day with the cells incubated with LPS and HKY (2.1fold higher than the control group)	Yersinia pseudotuberculosis	?	-	?

Synonyms

Synonyms	Comment	Organism
YopJ	-	Yersinia pseudotuberculosis

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Release 2023.1 (January 2023)