Literature summary for 3.4.22.B14 extracted from

Daczkowski, C.M.; Dzimianski, J.V.; Clasman, J.R.; Goodwin, O.; Mesecar, A.D.; Pegan, S.D.
Structural insights into the interaction of coronavirus papain-like proteases and interferon-stimulated gene product 15 from different species (2017), J. Mol. Biol., 429, 1661-1683 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with interferon-stimulated gene product 15 proteins from different species	Severe acute respiratory syndrome-related coronavirus

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome-related coronavirus	P0C6X7	human, i.e. SARS-CoV	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
proISG + H2O	i.e. proenzyme of interferon-stimulated gene product 15	Severe acute respiratory syndrome-related coronavirus	?	-	?

General Information

General Information	Comment	Organism
physiological function	SARS-CoV and MERS-CoV PLpros are both capable of fully processing proISG15 from human, mouse, camel and bat within 60 minutes. SARS PLpro is also able to fully process proISG15 from sheep and shrew within that same time but it has little to no activity against jackfish proISG15	Severe acute respiratory syndrome-related coronavirus

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Release 2023.1 (January 2023)