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Literature summary for 3.4.22.B14 extracted from

  • Kong, L.; Shaw, N.; Yan, L.; Lou, Z.; Rao, Z.
    Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus (2015), J. Biol. Chem., 290, 7160-7168 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B14

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli infectious bronchitis virus

Crystallization (Commentary)

Crystallization (Comment) Organism
to 2.15 A resolution. PLpro has a short blocking loop BL1-like loop. Access to a conserved catalytic triad consisting of Cys101, His264, and Asp275 is regulated by the flexible loop BL2 infectious bronchitis virus

Organism

Organism UniProt Comment Textmining
infectious bronchitis virus P0C6Y1
-
-
infectious bronchitis virus Beaudette P0C6Y1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KAGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus KAGG + 7-amino-4-methylcoumarin
-
 ?
KAGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette KAGG + 7-amino-4-methylcoumarin
-
 ?
KKAG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus KKAG + 7-amino-4-methylcoumarin
-
 ?
KKAG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette KKAG + 7-amino-4-methylcoumarin
-
 ?
LRGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus LRGG + 7-amino-4-methylcoumarin
-
 ?
LRGG-7-amido-4-methylcoumarin + H2O
-
 infectious bronchitis virus Beaudette LRGG + 7-amino-4-methylcoumarin
-
 ?
Lys48-Ub4 + H2O
-
 infectious bronchitis virus ?
-
 ?
Lys48-Ub4 + H2O
-
 infectious bronchitis virus Beaudette ?
-
 ?
Lys63-Ub4 + H2O
-
 infectious bronchitis virus ?
-
 ?
additional information PLpro can degrade Lys48- and Lys63-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin infectious bronchitis virus ?
-
 ?
additional information PLpro can degrade Lys48- and Lys63-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin infectious bronchitis virus Beaudette ?
-
 ?

Synonyms

Synonyms Comment Organism
PLpro
-
 infectious bronchitis virus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.67
-
 KKAG-7-amido-4-methylcoumarin pH 7.5, 25°C infectious bronchitis virus
3.23
-
 KAGG-7-amido-4-methylcoumarin pH 7.5, 25°C infectious bronchitis virus