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Literature summary for 3.4.22.8 extracted from

  • Bhattacharya, A.K.; Rana, K.C.; Raut, D.S.; Mhaindarkar, V.P.; Khan, M.I.
    An efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction (2011), Org. Biomol. Chem., 9, 5407-5413.
    View publication on PubMed
Search for more literature for 3.4.22.8

Inhibitors

Inhibitors Comment Organism Structure
diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica
dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
-
 Hathewaya histolytica

Organism

Organism UniProt Comment Textmining
Hathewaya histolytica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Hathewaya histolytica Nalpha-benzoyl-DL-arginine + 4-nitroaniline
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.032
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diallyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.036
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diallyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.07
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dimethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.08
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diethyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.09
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diallyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.14
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dibutyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.15
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diallyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.175
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dibutyl-2,4,4,9-tetramethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.22
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.278
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dimethyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b]-[1,4]diazepin-2-ylphosphonate
0.3
-
 IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dibutyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate
0.3
-
 IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dimethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
0.3
-
 IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diethyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
0.3
-
 IC50 above 0.3 mM, in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dibutyl-7-benzoyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
0.49
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica diethyl-2,4,4-trimethyl-8-nitro-2,3,4,5-tetrahydro-1H-benzo-[b][1,4]diazepin-2-ylphosphonate
0.78
-
 in 100 mM Tris-HCl buffer, pH 7.4, at 37°C Hathewaya histolytica dimethyl-7,8-dichloro-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-2-ylphosphonate