Literature summary for 3.4.22.8 extracted from

Gusman, H.; Grogan, J.; Kagan, H.M.; Troxler, R.F.; Oppenheim, F.G.
Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain (2001), FEBS Lett., 489, 97-100.

Search for more literature for 3.4.22.8

Inhibitors

Inhibitors	Comment	Organism	Structure
benzamidine	0.035 mM, 28% inhibition	Hathewaya histolytica
E-64	0.035 mM, 68% inhibition	Hathewaya histolytica
histatin 5	23.6 nM, 50% inhibition, competitive. The salivary protein could be used for the prevention or treatment of topical infactions such as those caused by Clostridium histolyticum	Hathewaya histolytica
iodoacetic acid	0.035 mM, 13% inhibition	Hathewaya histolytica
leupeptin	0.035 mM, complete inhibition	Hathewaya histolytica
additional information	no inhibition by 0.035 PMSF	Hathewaya histolytica
N-tosyl-Lys-chloromethylketone	0.035 mM, complete inhibition	Hathewaya histolytica

Organism

Organism	UniProt	Comment	Textmining
Hathewaya histolytica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-benzoyl-DL-arginine 4-nitroanilide + H2O	-	Hathewaya histolytica	N-benzoyl-DL-arginine + 4-nitroaniline	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00001	-	histatin 5	pH 7.4, 25°C	Hathewaya histolytica

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Release 2023.1 (January 2023)