Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.70 extracted from

  • Chen, F.; Liu, B.; Wang, D.; Wang, L.; Deng, X.; Bi, C.; Xiong, Y.; Wu, Q.; Cui, Y.; Zhang, Y.; Li, X.; Wang, Y.; Liu, B.; Cao, Y.
    Role of sortase A in the pathogenesis of Staphylococcus aureus-induced mastitis in mice (2014), FEMS Microbiol. Lett., 351, 95-103.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene srtA Staphylococcus aureus

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant strain, DELTASrtA Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
gene srtA
-
Staphylococcus aureus Newman D2C
-
gene srtA
-

Synonyms

Synonyms Comment Organism
SrtA
-
Staphylococcus aureus

General Information

General Information Comment Organism
malfunction deficiency of srtA impairs the release of pro-inflammatory cytokines in Staphylococcus aureus-induced mastitis. A DEKTASrtA mutant strain attenuates the inflammatory reaction in the mammary tissue of mice compared with wild-type Staphylococcus aureus challenge. The enzyme mutant strain impairs the induction of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, the mutant strain blocks the activation of nuclear factor kappaB and mitogen-activated protein kinases by attenuating the degradation and phosphorylation of signaling pathway molecules such as IkappaBalpha, p65 and p38. Staphylococcus aureus
physiological function sortase A is a key virulence factor in the pathogenesis of Staphylococcus aureus-induced mastitis in mice, overview Staphylococcus aureus