Cloned (Comment) | Organism |
---|---|
gene srtA | Staphylococcus aureus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a mutant strain, DELTASrtA | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
gene srtA | - |
Staphylococcus aureus Newman D2C | - |
gene srtA | - |
Synonyms | Comment | Organism |
---|---|---|
SrtA | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of srtA impairs the release of pro-inflammatory cytokines in Staphylococcus aureus-induced mastitis. A DEKTASrtA mutant strain attenuates the inflammatory reaction in the mammary tissue of mice compared with wild-type Staphylococcus aureus challenge. The enzyme mutant strain impairs the induction of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, the mutant strain blocks the activation of nuclear factor kappaB and mitogen-activated protein kinases by attenuating the degradation and phosphorylation of signaling pathway molecules such as IkappaBalpha, p65 and p38. | Staphylococcus aureus |
physiological function | sortase A is a key virulence factor in the pathogenesis of Staphylococcus aureus-induced mastitis in mice, overview | Staphylococcus aureus |