Literature summary for 3.4.22.70 extracted from

Lee, Y.J.; Han, Y.R.; Park, W.; Nam, S.H.; Oh, K.B.; Lee, H.S.
Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase (2010), Bioorg. Med. Chem. Lett., 20, 6882-6885.

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Inhibitors

Inhibitors	Comment	Organism
(2-methyl-1H-indol-3-yl)(oxo)acetic acid	-	Staphylococcus aureus
(6-hydroxy-1H-indol-3-yl)(oxo)acetic acid	-	Staphylococcus aureus
(6-methoxy-1H-indol-3-yl)(oxo)acetic acid	-	Staphylococcus aureus
1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione	-	Staphylococcus aureus
1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
1-pentyl-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ol	-	Staphylococcus aureus
1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
1-phenyl-4,9-dihydro-3H-beta-carboline	-	Staphylococcus aureus
1H-indol-3-yl(oxo)acetic acid	-	Staphylococcus aureus
2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid	-	Staphylococcus aureus
2-(1H-indol-3-yl)-2-oxo-N-phenylacetamide	-	Staphylococcus aureus
2-(2-methyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide	-	Staphylococcus aureus
2-(6-hydroxy-1H-indol-3-yl)-2-oxo-N-phenylacetamide	-	Staphylococcus aureus
2-(6-methoxy-1H-indol-3-yl)-2-oxo-N-phenylacetamide	-	Staphylococcus aureus
2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone	-	Staphylococcus aureus
3-(2-aminoethyl)-1H-indol-5-ol	-	Staphylococcus aureus
5-hydroxy-1H-indole-3-carbaldehyde	-	Staphylococcus aureus
6-hydroxy-2,3,4,9-tetrahydro-1H-beta-carbolin-1-one	-	Staphylococcus aureus
6-hydroxydihydro-beta-carboline	-	Staphylococcus aureus
7-hydroxy-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid	-	Staphylococcus aureus
7-methoxy-1-pentyl-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
7-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline	-	Staphylococcus aureus
7-methoxy-1-phenyl-4,9-dihydro-3H-beta-carboline	-	Staphylococcus aureus
7-methoxy-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid	-	Staphylococcus aureus
methyl 5-hydroxy-1H-indole-3-carboxylate	-	Staphylococcus aureus
additional information	not inhibited by 3-nitropropionate	Staphylococcus aureus
p-hydroxymercuribenzoic acid	-	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Synonyms

Synonyms	Comment	Organism
SrtA	-	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0106	-	pH and temperature not specified in the publication	Staphylococcus aureus	1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ol
0.0115	-	pH and temperature not specified in the publication	Staphylococcus aureus	7-methoxy-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline
0.025	-	pH and temperature not specified in the publication	Staphylococcus aureus	7-methoxy-1-phenyl-4,9-dihydro-3H-beta-carboline
0.042	-	pH and temperature not specified in the publication	Staphylococcus aureus	p-hydroxymercuribenzoic acid
0.061	-	pH and temperature not specified in the publication	Staphylococcus aureus	2-(2-methyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide
0.067	-	pH and temperature not specified in the publication	Staphylococcus aureus	6-hydroxydihydro-beta-carboline
0.069	-	pH and temperature not specified in the publication	Staphylococcus aureus	1H-indol-3-yl(oxo)acetic acid
0.097	-	pH and temperature not specified in the publication	Staphylococcus aureus	1-phenyl-4,9-dihydro-3H-beta-carboline
0.133	-	pH and temperature not specified in the publication	Staphylococcus aureus	(2-methyl-1H-indol-3-yl)(oxo)acetic acid
0.174	-	pH and temperature not specified in the publication	Staphylococcus aureus	2-(1H-indol-3-yl)-2-oxo-N-phenylacetamide