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Literature summary for 3.4.22.70 extracted from

  • Jang, K.H.; Chung, S.C.; Shin, J.; Lee, S.H.; Kim, T.I.; Lee, H.S.; Oh, K.B.
    Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos (2007), Bioorg. Med. Chem. Lett., 17, 5366-5369.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Aaptamine
-
Staphylococcus aureus
berberine chloride
-
Staphylococcus aureus
demethylaaptamine
-
Staphylococcus aureus
demethyloxyaaptamine
-
Staphylococcus aureus
isoaaptamine the suppression of fibronectin-binding activity by isoaaptamine highlights its potential for the treatment of Staphylococcus aureus infections via inhibition of SrtA activity Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
SrtA
-
Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50 for aaptamine is 0.0235 mg/ml, IC50 for isoaaptamine is 0.0037 mg/ml, IC50 for demethylaaptamine is 0.0172 mg/ml, IC50 for demethyloxyaaptamine is 0.0201 mg/ml, IC50 for berberine chloride is 0.0087 mg/ml Staphylococcus aureus additional information