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Literature summary for 3.4.22.70 extracted from

  • Kang, S.S.; Kim, J.G.; Lee, T.H.; Oh, K.B.
    Flavonols inhibit sortases and sortase-mediated Staphylococcus aureus clumping to fibrinogen (2006), Biol. Pharm. Bull., 29, 1751-1755.
    View publication on PubMed
Search for more literature for 3.4.22.70

Cloned(Commentary)

Cloned (Comment) Organism
SrtADELTA24 is expressed in Escherichia coli Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
beta-sitosterol-3-O-glucopyranoside
-
 Staphylococcus aureus
galangin IC50 for recombinant SrtA(DELTA24): 0.123 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
galangin-3-methyl ether IC50 for recombinant SrtA(DELTA24): 0.1179 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
isorhamnetin IC50 for recombinant SrtA(DELTA24): 0.05886 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
kaempferol IC50 for recombinant SrtA(DELTA24): 0.07794 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
morin IC50 for recombinant SrtA(DELTA24): 0.03739 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
myricetin IC50 for recombinant SrtA(DELTA24): 0.04403 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
quercetin IC50 for recombinant SrtA(DELTA24): 0.0527 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus
quercetin-3,3'-dimethyl ether IC50 for recombinant SrtA(DELTA24): 0.05361 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03739
-
 IC50 for recombinant SrtA(DELTA24): 0.03739 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus morin
0.04403
-
 IC50 for recombinant SrtA(DELTA24): 0.04403 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus myricetin
0.0527
-
 IC50 for recombinant SrtA(DELTA24): 0.0527 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus quercetin
0.05361
-
 IC50 for recombinant SrtA(DELTA24): 0.05361 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus quercetin-3,3'-dimethyl ether
0.05886
-
 IC50 for recombinant SrtA(DELTA24): 0.05886 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus isorhamnetin
0.07794
-
 IC50 for recombinant SrtA(DELTA24): 0.07794 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus kaempferol
0.1179
-
 IC50 for recombinant SrtA(DELTA24): 0.1179 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus galangin-3-methyl ether
0.123
-
 IC50 for recombinant SrtA(DELTA24): 0.123 mM, no antibacterial activity against Staphylococcus aureus Staphylococcus aureus galangin