Crystallization (Comment) | Organism |
---|---|
enzyme-inhibitor complex, hanging-drop method | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyl [(1S)-1-benzyl-3-chloro-2-oxopropyl]carbamate | potent and selective inhibitor | Severe acute respiratory syndrome-related coronavirus | |
benzyl [(1S)-3-chloro-1-(4-fluorobenzyl)-2-oxopropyl]carbamate | potent and selective inhibitor | Severe acute respiratory syndrome-related coronavirus | |
benzyl [(1S)-3-chloro-1-(naphthalen-2-ylmethyl)-2-oxopropyl]carbamate | potent and selective inhibitor | Severe acute respiratory syndrome-related coronavirus | |
methyl 3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-5-fluoro-4-oxopentanoate | potent and selective inhibitor | Severe acute respiratory syndrome-related coronavirus | |
tert-butyl (3S)-3-[[(benzyloxy)carbonyl]amino]-5-bromo-4-oxopentanoate | potent and selective inhibitor | Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Severe acute respiratory syndrome-related coronavirus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-KTSAVLQSGFRKMQ-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Dabcyl-KTSAVLQ + SGFRKMQ-EDANS | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000306 | - |
benzyl [(1S)-1-benzyl-3-chloro-2-oxopropyl]carbamate | - |
Severe acute respiratory syndrome-related coronavirus | |
0.000371 | - |
benzyl [(1S)-3-chloro-1-(naphthalen-2-ylmethyl)-2-oxopropyl]carbamate | - |
Severe acute respiratory syndrome-related coronavirus | |
0.00038 | - |
benzyl [(1S)-3-chloro-1-(4-fluorobenzyl)-2-oxopropyl]carbamate | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0004 | - |
tert-butyl (3S)-3-[[(benzyloxy)carbonyl]amino]-5-bromo-4-oxopentanoate | - |
Severe acute respiratory syndrome-related coronavirus | |
0.000512 | - |
methyl 3-([N-[(benzyloxy)carbonyl]-L-valyl]amino)-5-fluoro-4-oxopentanoate | - |
Severe acute respiratory syndrome-related coronavirus |