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Literature summary for 3.4.22.69 extracted from

  • Shao, Y.; Yang, W.; Peng, H.; Hsu, M.; Tsai, K.; Kuo, T.; Wang, A.H.; Liang, P.; Lin, C.; Yang, A.; Wong, C.
    Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors (2007), Chembiochem, 8, 1654-1657.
    View publication on PubMed
Search for more literature for 3.4.22.69

Inhibitors

Inhibitors Comment Organism Structure
2,5-bis[[(benzyloxy)carbonyl]amino]-1,2,5,6-tetradeoxy-1,6-di-1H-indol-3-yl-L-iditol
-
 Severe acute respiratory syndrome-related coronavirus
benzyl [(7S,8R,9R,10S)-8,9-dihydroxy-7,10-bis(1H-indol-3-ylmethyl)-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate highly selective for the 3CL protease and that no inhibitionis observed against HIV protease at 0.1 mM Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus
-
-
-

Synonyms

Synonyms Comment Organism
3CL protease
-
 Severe acute respiratory syndrome-related coronavirus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000073
-
 benzyl [(7S,8R,9R,10S)-8,9-dihydroxy-7,10-bis(1H-indol-3-ylmethyl)-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
-
 Severe acute respiratory syndrome-related coronavirus
0.00034
-
 2,5-bis[[(benzyloxy)carbonyl]amino]-1,2,5,6-tetradeoxy-1,6-di-1H-indol-3-yl-L-iditol
-
 Severe acute respiratory syndrome-related coronavirus