Protein Variants | Comment | Organism |
---|---|---|
C145A | no irreversible inactivation by benzotriazole esters | Severe acute respiratory syndrome-related coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(1H-benzimidazol-5-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
1-[(1H-indol-2-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
1-[(1H-indol-5-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
1-[[(5-fluoro-1H-indol-2-yl)carbonyl]oxy]-1H-1,2,3-benzotriazole | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
2-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]aniline | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N,N-diethylaniline | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N,N-dimethylaniline | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus | |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N-methylaniline | inhibition and irreversible mechanism-based inactivators, no irreversible inactivation with the C145A mutant enzyme | Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[4-(4-dimethylaminophenylazo)benzoic acid]-KTSAVLQSGFRKME-[5-[2'-(aminoethyl)amino]-naphthalenesulfonic acid] + H2O | - |
Severe acute respiratory syndrome-related coronavirus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3cLpro | - |
Severe acute respiratory syndrome-related coronavirus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000075 | - |
1-[(1H-indol-5-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000111 | - |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N,N-diethylaniline | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000121 | - |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N-methylaniline | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000123 | - |
1-[(1H-indol-2-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000138 | - |
1-[[(5-fluoro-1H-indol-2-yl)carbonyl]oxy]-1H-1,2,3-benzotriazole | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000174 | - |
4-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]-N,N-dimethylaniline | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000195 | - |
2-[(1H-1,2,3-benzotriazol-1-yloxy)carbonyl]aniline | - |
Severe acute respiratory syndrome-related coronavirus | |
0.0000229 | - |
1-[(1H-benzimidazol-5-ylcarbonyl)oxy]-1H-1,2,3-benzotriazole | - |
Severe acute respiratory syndrome-related coronavirus |