Cloned (Comment) | Organism |
---|---|
expression of FLAG-SMT3IP1 in COS-7 cells, coexpression with His6-ubiquitin. Overexpression of SMT3IP1 in cells results in the accumulation of Mdm2 in the nucleolus and increased stability of the p53 protein | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
SMT3IP1 | - |
Mus musculus |
SMT3IP1/SENP3 | - |
Mus musculus |
SUMO-specific protease | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | nucleolar SUMO-specific protease, SMT3IP1/SENP3, controls the p53Mdm2 pathway. SMT3IP1 interacts with p53 and Mdm2, and desumoylates both proteins. SMT3IP1 bound to the acidic domain of Mdm2, which also mediates the p53 interaction, and competes with p53 for binding. Increasing expression of SMT3IP1 suppresses Mdm2-mediated p53 ubiquitination and subsequent proteasomal degradation. Desumoylation activity of SMT3IP1 is not necessary for p53 stabilization | Mus musculus |