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Literature summary for 3.4.22.68 extracted from

  • Jiang, M.; Chiu, S.Y.; Hsu, W.
    SUMO-specific protease 2 in Mdm2-mediated regulation of p53 (2011), Cell Death Differ., 18, 1005-1015.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.68

Cloned(Commentary)

Cloned (Comment) Organism
expression of SENP1 and SENP2 isozymes in HCT-116 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information a genetic mutation inactivating all three gene products of SENP2 is generated by alternative splicing Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
small ubiquitin-related modifier-Mdm2 + H2O Mus musculus co-localization of SENP2 with SUMO conjugated Mdm2. SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies small ubiquitin-related modifier-protein + Mdm2
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 r
small ubiquitin-related modifier-protein + H2O Mus musculus SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins small ubiquitin-related modifier-protein + protein
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 r

Organism

Organism UniProt Comment Textmining
Mus musculus
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 isozymes SENP2, SENP2-M, and SENP2-S
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Source Tissue

Source Tissue Comment Organism Textmining
trophoblast
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 Mus musculus
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trophoblast stem cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
small ubiquitin-related modifier-Mdm2 + H2O co-localization of SENP2 with SUMO conjugated Mdm2. SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies Mus musculus small ubiquitin-related modifier-protein + Mdm2
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 r
small ubiquitin-related modifier-Mdm2 + H2O SENP2 catalyzes the desumoylation process of Mdm2 Mus musculus small ubiquitin-related modifier-protein + Mdm2
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 r
small ubiquitin-related modifier-protein + H2O SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins Mus musculus small ubiquitin-related modifier-protein + protein
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 r

Synonyms

Synonyms Comment Organism
SENP2
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 Mus musculus
SUMO-specific protease 2
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 Mus musculus

General Information

General Information Comment Organism
malfunction targeted disruption of SENP2 impairs the G-S transition required for mitotic and endoreupliation cell cycles during expansion of trophoblast stem cells and their differentiation into polyploidy cells, respectively. The disruption disturbs the subcellular distribution and SUMO modification of Mdm2, leading to interference with p53 degradation. SUMO conjugated Mdm2 is elevated in the SENP2-null cells Mus musculus
additional information SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies Mus musculus
physiological function the key genetic pathway SENP2-Mdm2-p53 is essential for trophoblast development, mechanism underlying the isoform-specific SENP2 mediated regulation of Mdm2 critical for genome integrity in p53-induced cellular stress, overview. SENP2 catalyzes the desumoylation process of Mdm2. Dynamic SUMO modification is involved in a variety of cellular processes, including protein trafficking, transcriptional regulation, cell survival and death, and protein stability. High levels of SENP2, but not the other two forms, SENP2-M and SENP2-S, drastically diminished the cellular levels of p53. SENP2-mediated downregulation of p53 and p21, but not SENP2-mediated desumoylation of Mdm2, is sensitive to the Nutlin-3 treatment Mus musculus