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Literature summary for 3.4.22.68 extracted from

  • Li, S.J.; Hochstrasser, M.
    The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity (2003), J. Cell. Biol., 160, 1069-1081.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.68

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear envelope the NH2-terminal domain of the enzyme, residues between position 144 and 346, includes sequences necessary and sufficient to concentrate Ulp1 at nuclear envelope Saccharomyces cerevisiae 5635
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme is specifically required for cell cycle progression ?
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 ?
SMT3precursor + H2O Saccharomyces cerevisiae
-
 ?
-
 ?
SUMO-1 protein + H2O Saccharomyces cerevisiae
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the NH2-terminal regulatory domain of Ulp1 restricts Ulp1 activity towards certain sumoylated proteins while enabling the cleavage of others, the COOH-terminal catalytic domain of Ulp1 is both necessary and sufficient for the essential function of the protein in cell cycle progression and for Smt3 precursor cleavage Saccharomyces cerevisiae ?
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 ?
additional information the enzyme is specifically required for cell cycle progression Saccharomyces cerevisiae ?
-
 ?
SMT3precursor + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
SUMO-1 protein + H2O
-
 Saccharomyces cerevisiae ?
-
 ?