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Literature summary for 3.4.22.66 extracted from

  • Yokoyama, M.; Oka, T.; Takagi, H.; Kojima, H.; Okabe, T.; Nagano, T.; Tohya, Y.; Sato, H.
    A proposal for a structural model of the feline calicivirus protease bound to the substrate peptide under physiological conditions (2017), Front. Microbiol., 8, 1383 .
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
molecular model of the protease bound with octapeptide FRLEADDG containing a cleavage site of the capsid precursor protein feline calicivirus

Inhibitors

Inhibitors Comment Organism Structure
1,6-di(propan-2-yl)-N-(4-[[4-(prop-2-en-1-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl]-1,3-thiazol-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide compound is predicted to bind to feline calicivirus proteases in a mode similar to that of the authentic substrate, and has the ability to inhibit viral protease activity in vitro and in the cells, and to suppress viral replication in FCV-infected cells. The authentic substrate and anti-FCV compound share a highly conserved binding site feline calicivirus

Organism

Organism UniProt Comment Textmining
feline calicivirus
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feline calicivirus F4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
F4 capsid precursor protein + H2O
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 feline calicivirus ?
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 ?
F4 capsid precursor protein + H2O
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 feline calicivirus F4 ?
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 ?
F4 NS6-7 protein + H2O strain F4 protein containing protease and RNA-dependent RNA-polymerase region feline calicivirus ?
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 ?
F4 NS6-7 protein + H2O strain F4 protein containing protease and RNA-dependent RNA-polymerase region feline calicivirus F4 ?
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 ?
FRLEADDG + H2O
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 feline calicivirus FRLE + ADDG
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 ?
FRLEADDG + H2O
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 feline calicivirus F4 FRLE + ADDG
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 ?