Any feedback?
Literature summary for 3.4.22.65 extracted from
- House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions (2013), Int. Forum Allergy Rhinol., 3, 630-635.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dermatophagoides pteronyssinus | P08176 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Der p 1 | - |
Dermatophagoides pteronyssinus |
| house dust mite allergen | - |
Dermatophagoides pteronyssinus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | sinonasal epithelial exposure to house dust mite antigen enzyme Der p 1 decreases expression of tight junction proteins, representing a potential mechanism for increased permeability and presentation of antigens across the sinonasal epithelial layer. Enzyme Der p 1-exposed human sinonasal cells show a marked decrease in transepithelial resistance when compared to control cells, with decreased expression of tight junction proteins claudin-1 and junction adhesion molecule-A (JAM-A). Epithelial permeability is highly dependent upon the integrity of tight junctions, cell-cell adhesion complexes located at the apical aspect of the lateral membrane of polarized epithelial cells. Importance of Der p 1 cysteine protease activity directed against airway epithelia | Dermatophagoides pteronyssinus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
