Literature summary for 3.4.22.65 extracted from

Herman, J.; Thelen, N.; Smargiasso, N.; Mailleux, A.C.; Luxen, A.; Cloes, M.; De Pauw, E.; Chevigne, A.; Galleni, M.; Dumez, M.E.
Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus (2014), Biochim. Biophys. Acta, 1840, 1117-1124.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Der p 1 propeptide	the propeptide of 80 amino acids plays an essential role in zymogen folding (as an intramolecular chaperone) and in the inhibition of its own enzymatic activity	Dermatophagoides pteronyssinus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pro-Der p 3 + H2O	Dermatophagoides pteronyssinus	activation	Der p 3 + Der p 3 propeptide	-	?
pro-Der p 6 + H2O	Dermatophagoides pteronyssinus	activation	Der p 6 + Der p 6 propeptide	-	?
pro-Der p 9 + H2O	Dermatophagoides pteronyssinus	activation	Der p 9 + Der p 9 propeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Dermatophagoides pteronyssinus	P08176	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the Der p 1 enzyme propeptide of 80 amino acids plays an essential role in zymogen folding as an intramolecular chaperone and in the inhibition of its own enzymatic activity	Dermatophagoides pteronyssinus

Source Tissue

Source Tissue	Comment	Organism	Textmining
midgut	immunohistochemic localisation of the enzyme	Dermatophagoides pteronyssinus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-Der p 3 + H2O	activation	Dermatophagoides pteronyssinus	Der p 3 + Der p 3 propeptide	-	?
pro-Der p 3 + H2O	activation, the enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen	Dermatophagoides pteronyssinus	Der p 3 + Der p 3 propeptide	-	?
pro-Der p 6 + H2O	activation	Dermatophagoides pteronyssinus	Der p 6 + Der p 6 propeptide	-	?
pro-Der p 6 + H2O	pro-Der p 6 zymogen is recombinantly produced in Pichia pastoris, activation mechanism analysis by mite protease Der p 1, overview. The enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen. The N-terminal sequence of rDer p 6 is V35IGGDQ. The propeptide of proDer p 6 inhibits the proteolytic activity of protease Der p 6, but once cleaved, it is degraded by the protease	Dermatophagoides pteronyssinus	Der p 6 + Der p 6 propeptide	-	?
pro-Der p 9 + H2O	activation	Dermatophagoides pteronyssinus	Der p 9 + Der p 9 propeptide	-	?
pro-Der p 9 + H2O	activation, the enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen	Dermatophagoides pteronyssinus	Der p 9 + Der p 9 propeptide	-	?

Synonyms

Synonyms	Comment	Organism
Der p 1	-	Dermatophagoides pteronyssinus

General Information

General Information	Comment	Organism
evolution	enzyme Der p 1 is a cysteine protease from the papain family	Dermatophagoides pteronyssinus
additional information	activation mechanism analysis of the two other serine proteases, Der p 6 (chymotrypsin-like) and Der p 9 (collagenase)zymogen by mite protease Der p 1, overview	Dermatophagoides pteronyssinus
physiological function	the enzyme is is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus. Der p 1 in either its recombinant formor in the natural context of house dustmite extracts specifically cleaves all zymogens, thus establishing its role as a major activator of both mite cysteine and serine proteases	Dermatophagoides pteronyssinus

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Release 2023.1 (January 2023)