Literature summary for 3.4.22.65 extracted from

Takai, T.; Mizuuchi, E.; Kikuchi, Y.; Nagamune, T.; Okumura, K.; Ogawa, H.
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation (2006), Int. Arch. Allergy Immunol., 139, 181-187.

Search for more literature for 3.4.22.65

Application

Application	Comment	Organism
diagnostics	maturation systems using Pro-Der p 1 without the prodomain glycosylation are useful for the efficient preparation of a recombinant mature allergen	Dermatophagoides pteronyssinus
medicine	allergen is associated with allergic diseases such as bronchial asthma, rhinitis, and atopic dermatitis	Dermatophagoides pteronyssinus

Cloned(Commentary)

Cloned (Comment)	Organism
expression and maturation of prepro-Der p 1 and its mutants in Pichia pastoris. Maturation systems using Pro-Der p 1 without the prodomain glycosylation are useful for the efficient preparation of a recombinant mature allergen	Dermatophagoides pteronyssinus
expression in Pichia pastoris	Dermatophagoides pteronyssinus

Protein Variants

Protein Variants	Comment	Organism
N52Q	mutant with disrupted N-glycosylation motif in the prodomain, decreases the productivity and accelerates the maturation	Dermatophagoides pteronyssinus

Organism

Organism	UniProt	Comment	Textmining
Dermatophagoides pteronyssinus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	N-glycosylation of the prosequences decelerated the maturation. Systems using Pro-Der p 1 without the prodomain glycosylation are useful for the efficient preparation of a recombinant mature allergen	Dermatophagoides pteronyssinus

Purification (Commentary)

Purification (Comment)	Organism
culture supernatants recovered, buffer exchange by gel filtration, equilibration with 100 mM sodium acetate buffer (pH 4)	Dermatophagoides pteronyssinus

Synonyms

Synonyms	Comment	Organism
Der p 1	-	Dermatophagoides pteronyssinus
major house dust mite allergen	-	Dermatophagoides pteronyssinus

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Release 2023.1 (January 2023)