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Literature summary for 3.4.22.65 extracted from

  • Gough, L.; Schulz, O.; Sewell, H.F.; Shakib, F.
    The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response (1999), J. Exp. Med., 190, 1897-1902.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
cysteine the enzyme is completely dependent on preactivation with cysteine Dermatophagoides pteronyssinus

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
 Dermatophagoides pteronyssinus
iodoacetamide
-
 Dermatophagoides pteronyssinus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Dermatophagoides pteronyssinus Der p 1 is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The proteolytic activity of Der p 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dermatophagoides pteronyssinus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
feces
-
 Dermatophagoides pteronyssinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CD25 + H2O
-
 Dermatophagoides pteronyssinus ?
-
 ?
additional information Der p 1 is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The proteolytic activity of Der p 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production Dermatophagoides pteronyssinus ?
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 ?