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Literature summary for 3.4.22.64 extracted from

  • Chan, A.H.; Burgener, S.S.; Vezyrgiannis, K.; Wang, X.; Acklam, J.; Von Pein, J.B.; Pizzuto, M.; Labzin, L.I.; Boucher, D.; Schroder, K.
    Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1beta-converting enzyme (2023), Life Sci. Alliance, 6, e202301908.
    View publication on PubMed
Search for more literature for 3.4.22.64

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-11 auto-processing activates the enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin-D + H2O Mus musculus
-
 ?
-
 ?
Pro-interleukin-1beta + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-11, the murine counterpart of caspase-4, acquires protease activity within the noncanonical inflammasome by forming a dimer that self-cleaves at D285 to cleave GSDMD Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell primary Mus musculus
-
marrow cell primary Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-WEHD-7-amido-4-methylcoumarin + H2O
-
 Mus musculus acetyl-WEHD + 7-amino-4-methylcoumarin
-
 ?
gasdermin-D + H2O
-
 Mus musculus ?
-
 ?
additional information dimerised caspase-11 cannot cleave pro-interleukin-1beta of either species, mouse or human Mus musculus ?
-
-
Pro-interleukin-1beta + H2O
-
 Mus musculus ?
-
 ?

General Information

General Information Comment Organism
metabolism dimerisation of caspase-4, but not caspase-11, induces the cleavage of human and murine pro-IL-1beta in cells Mus musculus
additional information caspase-11 auto-processing activates the enzyme Mus musculus
physiological function the noncanonical inflammasome is a signalling complex critical for cell defence against cytosolic Gram-negative bacteria. A key step in the human noncanonical inflammasome pathway involves unleashing the proteolytic activity of caspase-4 within this complex. The enzyme directly cleaves GSDMD, which is consistent with established functions for murine caspase-11 in initiating cell death independently of caspase-1. Caspase-11, the murine counterpart of caspase-4, acquires protease activity within the noncanonical inflammasome by forming a dimer that self-cleaves at D285 to cleave gasdermin D (GSDMD) Mus musculus