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Literature summary for 3.4.22.64 extracted from

  • Ye, Z.; Zhang, L.; Li, R.; Dong, W.; Liu, S.; Li, Z.; Liang, H.; Wang, L.; Shi, W.; Malik, A.B.; Cheng, K.T.; Liang, X.
    Caspase-11 mediates pyroptosis of tubular epithelial cells and septic acute kidney injury (2019), Kidney Blood Press. Res., 44, 465-478.
    View publication on PubMed
Search for more literature for 3.4.22.64

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide LPS from Escherichia coli strain 0111:B4 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
-
 ?
-
 ?
gasdermin D + H2O Mus musculus C57BL
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
-
Mus musculus C57BL P70343 cf. caspase-4, EC 3.4.22.57
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
renal tubular epithelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
-
 Mus musculus ?
-
 ?
gasdermin D + H2O
-
 Mus musculus C57BL ?
-
 ?

Expression

Organism Comment Expression
Mus musculus increase in pyroptosis-related protein expression is induced by LPS up

General Information

General Information Comment Organism
malfunction the increase in pyroptosis-related protein expression induced by LPS is attenuated with caspase-11 knockout, both in vitro and in vivo. Comparison of pyroptotic cell death of tubular epithelial cells in renal tissue of wild-type mice and caspase-11-/- mice after an LPS challenge. Knockout of caspase-11 improves animal survival after lipopolysaccharide stimulation. Knockout of caspase-11 results in decreased expression of mature IL-1beta in kidney tissue following endotoxemia. Similarly, serum IL-1beta levels are also significantly lower in caspase-11-/- mice than in control mice after LPS challenge Mus musculus
physiological function caspase-11 mediates pyroptosis of tubular epithelial cells and septic acute kidney injury. Caspase-11 induces pyroptosis, a form of programmed cell death that plays a critical role in endotoxic shock. LPS-induced sepsis results in lytic death of RTECs, accompanied by increased expression of the pyroptosis-related proteins caspase-11 and Gsdmd. Caspase-11 activation is required for generation of mature IL-1beta and Gsdmd in endotoxic acute kidney injury (AKI), mechanisms by which caspase-11 activation induces AKI, overview Mus musculus