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Literature summary for 3.4.22.64 extracted from

  • Bibo-Verdugo, B.; Joglekar, I.; Karadi Giridhar, M.N.; Ramirez, M.L.; Snipas, S.J.; Clark, A.C.; Poreba, M.; Salvesen, G.S.
    Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold (2022), J. Biol. Chem., 298, 101931.
    View publication on PubMed
Search for more literature for 3.4.22.64

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
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Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
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 Mus musculus ?
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additional information mouse caspase-11 has an inadequate capacity to cleave pro-IL-1beta. It cleaves gasdermin D more efficiently than pro-IL-1beta Mus musculus ?
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Synonyms

Synonyms Comment Organism
mouse caspase-4
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 Mus musculus

General Information

General Information Comment Organism
metabolism inflammatory caspases drive two recognized pyroptotic pathways. Caspase-1 activates the canonical pathway, whereas mouse caspase-4 (also known as caspase-11) and human caspase-4 and caspase-5 initiate the noncanonical pathway. Caspase-4 and caspase-11 are usually considered to be orthologues, even though they may have different biological activities Mus musculus