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Literature summary for 3.4.22.64 extracted from

  • Zaslona, Z.; Flis, E.; Nulty, C.; Kearney, J.; Fitzgerald, R.; Douglas, A.R.; McNamara, D.; Smith, S.; ONeill, L.A.J.; Creagh, E.M.
    Caspase-4 a therapeutic target for peptic ulcer disease (2020), ImmunoHorizons, 4, 627-633.
    View publication on PubMed
Search for more literature for 3.4.22.64

Protein Variants

Protein Variants Comment Organism
additional information generation of bone marrow-derived Casp-/- macrophages Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
prostaglandin 2 PGE2, inhibits cpyroptosis and IL-1beta secretion in macrophages Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric antrum enhanced caspase-11 expression in gastric antrum biopsies from ulcer model mice Mus musculus
-
macrophage bone marrow-derived macrophages, caspase-11 expression is increased following Helicobacter pylori infection in macrophages Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CASP11
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus caspase-11 expression is increased following Helicobacter pylori strain NCTC11638 infection in macrophages. Prostaglandins (PGs) inhibit caspase-11 upregulation, IL-1beta production, and pyroptosis in mice up

General Information

General Information Comment Organism
evolution caspase-11 belongs to the inflammatory caspases Mus musculus
malfunction prostaglandin 2 (PGE2) inhibits caspase-11-driven IL-1beta production and pyroptosis in a murine model of peritonitis. In vivo inhibition of caspase-11 will effectively attenuate the inflammatory and pyroptotic cascades that occur during ulcer development or perforation Mus musculus
physiological function murine caspase-11 is an essential mediator of sepsis. Primary murine macrophages infected with Helicobacter pylori upregulate caspase-1 (the orthologue of human caspase-4, EC 3.4.22.57), activate caspase-1, and secrete IL-1beta. Pathological role of caspase-4/11 in peptic ulcer disease, caspase-11 contributes to the inflammation and mucosal damage that occur during ulcer formation. Perforated peptic ulcers can lead to peritonitis and, subsequently, sepsis. Caspase-11-mediated pyroptosis causes the release of damage-associated molecular patterns (DAMPs) and ATP, which can subsequently activate NLRP3 and caspase-1, which will serve to further boost pyroptosis levels Mus musculus