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Literature summary for 3.4.22.64 extracted from

  • Cheng, Y.; Manabe, I.; Hayakawa, S.; Endo, Y.; Oishi, Y.
    Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages (2023), Front. Immunol., 14, 1009973.
    View publication on PubMed
Search for more literature for 3.4.22.64

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide LPS, activates caspase-11. Caspase-11 can be activated by binding to internalized LPS Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
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endosome
-
 Mus musculus 5768
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Golgi apparatus caspase-11 is partly localized to the Golgi but not the endoplasmic reticulum Mus musculus 5794
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Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification LPS activates pro-caspase-11 cleavage and activation of caspase-11 functions Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage bone marrow-derived macrophages Mus musculus
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Synonyms

Synonyms Comment Organism
CASP4
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus mRNA expression of Casp4, which encodes caspase-11, starts to increase at 1 h and reaches its peak at 6 h after treatment with LPS up

General Information

General Information Comment Organism
malfunction deletion of the Casp4 gene, which encodes caspase-11, impairs the activation of S1P and SREBP1 as well as alters the expression of genes regulated by SREBP1 in macrophages. Casp4 deletion tends to decrease the upregulation of Srebf1a expression induced by LPS, though the difference does not reach statistical significance. This attenuation of Srebf1a induction in Casp4-/- cells might be due to reduced SREBP1 activity because the Srebf1 promoter is autoregulated by SREBP Mus musculus
metabolism the caspase-11/S1P pathway activates SREBP1 in response to LPS, thus regulating subsequent macrophage activation Mus musculus
physiological function mouse caspase-11 contributes to SREBP1 activation in the inflammatory response of macrophages, site-1 protease (S1P) is an enzyme that mediates the cleavage and activation of SREBP1. Caspase-11 promotes the processing of S1P - caspase-11 directly associates with S1P and cleaves it at a specific site - and is required for SREBP1 activation in the inflammatory response to LPS. Caspase-11 is required for nuclear translocation of SREBP1 in response to LPS and is important for SREBP1-dependent gene regulation Mus musculus