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Literature summary for 3.4.22.64 extracted from

  • Mamantopoulos, M.; Frising, U.C.; Asaoka, T.; van Loo, G.; Lamkanfi, M.; Wullaert, A.
    El Tor biotype Vibrio cholerae activates the caspase-11-independent canonical Nlrp3 and pyrin inflammasomes (2019), Front. Immunol., 10, 2463.
    View publication on PubMed
Search for more literature for 3.4.22.64

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide LPS, activates the enzyme Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of caspase11-/- mice and caspase1/11-/- mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Mus musculus 5829
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Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Mus musculus C57BL/6J P70343 cf. caspase-4, EC 3.4.22.57
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage primary bone marrow-derived macrophages Mus musculus
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General Information

General Information Comment Organism
physiological function the Classical biotype of Vibrio cholerae triggers caspase-11-dependent non-canonical inflammasome activation in macrophages following CT-mediated cytosolic delivery of LPS. In contrast to the Classical biotype, El Tor Vibrio cholerae induces IL-1beta maturation and secretion in a caspase-11- and CT-independent manner, overview. El Tor Vibrio cholerae (N16961 strain, originally isolated from a cholera patient in Bangladesh) engages the canonical Nlrp3 inflammasome for IL-1b secretion through its accessory hlyA toxin. Vibrio cholerae El Tor biotype does not trigger caspase-11 activation, but instead triggers parallel Nlrp3- and pyrin-dependent pathways toward canonical inflammasome activation to induce IL-1beta-mediated inflammatory responses Mus musculus