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Literature summary for 3.4.22.64 extracted from

  • Krause, K.; Daily, K.; Estfanous, S.; Hamilton, K.; Badr, A.; Abu Khweek, A.; Hegazi, R.; Anne, M.N.; Klamer, B.; Zhang, X.; Gavrilin, M.A.; Pancholi, V.; Amer, A.O.
    Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages (2019), EMBO Rep., 20, e48109.
    View publication on PubMed
Search for more literature for 3.4.22.64

Protein Variants

Protein Variants Comment Organism
additional information generation of casp11-/- macrophages Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Mus musculus 5739
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Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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additional information CASP11 is not expressed in healthy tissue unless induced by infection or other pathologic stress Mus musculus
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Synonyms

Synonyms Comment Organism
CASP11
-
 Mus musculus
caspase-11/caspase-4
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus CASP11 is induced by infection or other pathologic stress. Upregulation of CASP11 in cell lysates of infected wild-type as well as casp1-/- macrophages up

General Information

General Information Comment Organism
malfunction CASP11 deficiency improves clearance of intracellular MRSA in vitro and in vivo. Caspase-11 deficiency allows increased association of MRSA-containing vacuoles with mitochondria. Induction of mitochondrial superoxide by antimycin A (Ant A) improves MRSA eradication in casp11-/- cells, where mitochondria remain in the vicinity of the bacterium, while in wild-type macrophages, Ant A does not affect MRSA persistence. When mitochondrial dissociation is prevented by the actin depolymerizing agent cytochalasin D, Ant A effectively reduces MRSA numbers. Moreover, the absence of CASP11 leads to reduced cleavage of CASP1, IL-1beta, and CASP7, as well as to reduced production of CXCL1/KC. Reduced secretion of IL-1alpha and CXCL1/KC is found only in casp11-/- macrophages, not in caspase1-/- macrophages. Mitochondrial ROS (mtROS) contribute to MRSA clearance in casp11-/- macrophages Mus musculus
metabolism inhibition of the actin cytoskeleton prevents the dissociation of MRSA-containing phagosomes from mitochondria and leads to bacterial killing. Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages Mus musculus
physiological function inflammatory caspase-11/caspase-4 (CASP11) contributes to non-canonical NLRP3 inflammasome activation and subsequent inflammation. Methicillin-resistant Staphylococcus aureus (MRSA) is capable of persisting within professional phagocytes including macrophages. Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages, role for CASP11 in facilitating MRSA survival within murine macrophages and in promoting the persistence of Gram-positive bacteria, overview. MRSA actively prevents the recruitment of mitochondria to the vicinity of the vacuoles they reside in to avoid intracellular demise. This process requires CASP11 Mus musculus