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Literature summary for 3.4.22.64 extracted from

  • Kovacs, S.B.; Oh, C.; Maltez, V.I.; McGlaughon, B.D.; Verma, A.; Miao, E.A.; Aachoui, Y.
    Neutrophil caspase-11 isessential to defend against a cytosol-invasive bacterium (2020), Cell Rep., 32, 107967.
    View publication on PubMed
Search for more literature for 3.4.22.64

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Mus musculus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
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 ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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neutrophil
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
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 Mus musculus ?
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 ?

General Information

General Information Comment Organism
metabolism although both caspase-1 and caspase-11 can cleave gasdermin D in macrophages and neutrophils, NLRC4-activated caspase-1 triggers pyroptosis in macrophages, but this pathway does not trigger pyroptosis in neutrophils. In contrast, caspase-11 triggers pyroptosis in both macrophages and neutrophils. Cell fates are dictated not simply by the pathogen or inflammasome, but also by how the cell is wired to respond to detection events. In macrophages, caspase-1 is more efficient than caspase-11 at cleaving gasdermin D in response to Burkholderia thailandensis. Caspase-1 alone cannot clear Burkholderia thailandensis infection Mus musculus
physiological function macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)-18 and driving an essential interferon (IFN)-gamma response that primes caspase-11. The neutrophil caspase-11 is essential to defend against the cytosol-invasive bacterium. Caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. The IFN-gamma-producing cells are a mixture of natural killer (NK) and T cells. In neutrophils, caspase-1 (EC 3.4.22.36) and caspase-11 activation lead to gasdermin D cleavage, but only caspase-11 activation leads to pyroptosis that is necessary for clearance of this cytosol-invasive pathogen in vivo. The caspase-11 inflammasome monitors for lipopolysaccharide (LPS) contamination as a marker for the virulence trait of cytosolic invasion. Cellular detection mechanism, overview. Multiple lymphocyte populations respond to Burkholderia thailandensis infection. Absolute requirement for caspase-11 and gasdermin D in neutrophils during Burkholderia thailandensis infection in mice Mus musculus