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Literature summary for 3.4.22.64 extracted from

  • Huang, X.; Feng, Y.; Xiong, G.; Whyte, S.; Duan, J.; Yang, Y.; Wang, K.; Yang, S.; Geng, Y.; Ou, Y.; Chen, D.
    Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis (2019), Cell Biosci., 9, 31.
    View publication on PubMed
Search for more literature for 3.4.22.64

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharides the non-canonical inflammatory pathway-induced pyroptosis is induced by lipopolysaccharide (LPS) on the surface of gram-negative bacteria. This activates caspase-11. LPS to directly enter the cell and activate caspase-11 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is produced as procaspase-11 and activated by proteolytic cleavage. After transcription and translation, a large amount of procaspase-11 and proIL-1beta, proIL-18 is generated and distributed in the cytoplasm. LPS binds with procaspase-11, initiate procaspase-11 oligomerization and form mature/activated caspase-11 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
-
 Mus musculus ?
-
 ?

Expression

Organism Comment Expression
Mus musculus TLR 2 promotes the expression of caspase-11 by activating the NF-kappaB-transduction of the Myd88. TLR 3 also promotes the expression of caspase-11 by inducing the production of IFN-alpha/beta (IFN-I). After transcription and translation, a large amount of procaspase-11 and proIL-1beta, proIL-18 is generated and distributed in the cytoplasm up

General Information

General Information Comment Organism
evolution caspase-11 belongs to the caspase family and is an homologous protein of caspase-1, phylogenetic tree, relationship between caspase-1 and caspase-11 and tertiary structure comparison, overview Mus musculus
malfunction binding-deficient CARD-domain point mutants in procaspase-11 do not respond to LPS with oligomerization or activation and failed to induce pyroptosis upon LPS electroporation or bacterial infections, indicating that the binding site of LPS is located on the CARD domain of procaspase-11. Caspase-11 deficiency does not affect the maturation of IL-1beta and IL-18 following Gram-negative bacterial injection, while the mature IL-1beta and IL-18 in CASP1-/-/CASP11-/- macrophages are significantly reduced Mus musculus
metabolism caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis. Pyroptosis is a type of programmed cell death that, along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to Gram-negative bacteria. It is induced by lipopolysaccharide (LPS) on the surface of Gram-negative bacteria. This activates caspase-11 which, in turn, activates a series of downstream proteins eventually forming protein pores on the cell membrane and inducing cell sacrificial processes. Key role caspase-11 plays in the activation of pyroptosis and inflammation. The non-canonical inflammatory pathway is divided into two parts: initiation and excitation, both of which are activated by LPS, regulation of caspase-11 involved non-canonical inflammation, detailed overview Mus musculus
additional information morphological changes of programmed cell death, detailed overview Mus musculus
physiological function caspase-11 is a specific sensor for intracellular lipopolysaccharide recognition. Key role caspase-11 plays in the activation of pyroptosis and inflammation. When caspase-11 is activated, it induces the downstream substrate GSDM D to cleave into the N terminal and C terminal domains, with the N-terminal domain on the cell membrane. Cleavage removes the C-terminal fragment (GSDMD-CT). The N-terminal oligomerizes in membranes to form pores that triggers pyroptosis Mus musculus