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Literature summary for 3.4.22.64 extracted from

  • Liu, M.; Cao, W.; Qin, X.; Tong, J.; Wu, X.; Cheng, Y.
    Caspase-11 contributes to pain hypersensitivity in the later phase of CFA-induced pain of mice (2023), Brain Res., 1801, 148172.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information complete Freund's adjuvant (CFA) injection significantly decreases the hind paw mechanical pain threshold in Von Frey test on 1-7 days after injection and increases the caspase-11 level of ipsilateral dorsal horn of spinal cord on day 2 and day 5 after injection. Compared to wild-type mice, caspase-11-/- mice show significantly higher mechanical pain threshold in the later phase of CFA-induced pain, but not in the early phase, and have no significant difference in 5% formalin induced licking and flinching behavior. In addition, the microglial activation, and the mRNA levels of caspase-1 and IL-18 in the spinal cord of caspase-11-/- mice restore to baseline on the day 5 after CFA injection, but not in wild-type mice. Phenotypes, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
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 Mus musculus
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Synonyms

Synonyms Comment Organism
caspase-11
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 Mus musculus

General Information

General Information Comment Organism
physiological function caspase-11 contributes to in ipsilateral dorsal horn of spinal cord, and consequently to pain hypersensitivity in the later phase of complete Freund's adjuvant (CFA)-induced pain of mice. Persistent neuroinflammation and central sensitization play important roles in the pathogenesis of chronic pain disease. Caspase-11 is a critical modulator of inflammation of the central nervous system Mus musculus