Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.64 extracted from

  • Perlee, D.; de Beer, R.; Florquin, S.; van der Poll, T.; van't Veer, C.; de Vos, A.F.
    Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation (2020), Am. J. Physiol. Lung Cell Mol. Physiol., 319, L105-L114.
    View publication on PubMed
Search for more literature for 3.4.22.64

Protein Variants

Protein Variants Comment Organism
additional information generation of Casp11-/- mice. Caspase-11 deficiency impairs bacterial clearance in the lung, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Mus musculus P70343 cf. caspase-4, EC 3.4.22.57
-
Mus musculus C57BL6 P70343 cf. caspase-4, EC 3.4.22.57
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-
macrophage
-
 Mus musculus
-
neutrophil
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
CASP11
-
 Mus musculus
CASP4
-
 Mus musculus

General Information

General Information Comment Organism
malfunction low-dose Klebsiella pneumoniae infection via the airways to induce a gradually evolving pneumosepsis shows that Casp11-deficient mice display increased bacterial numbers in the lung 12 h and 48 h after inoculation with reduced IL-1alpha levels in bronchoalveolar lavage fluid and increased TNF levels in the lung of Casp11-/- mice at 48 h after inoculation. Caspase-11 deficiency impairs bacterial clearance in the lung, but has no effect on cell death in the lung. Caspase-11 deficiency does not influence lung pathology evoked by Klebsiella Mus musculus
physiological function caspase-11 is an intracellular receptor for lipopolysaccharide and regulates pyroptosis, a specific form of inflammatory cell death, which aids in host defense against intracellular gram-negative bacteria. Caspase-11 is also implicated in blood coagulation, local fibrin formation contributes to protective immunity against Klebsiella infection of the lung. Caspase-11 contributes to protective immunity against Klebsiella pneumoniae possibly by activation of blood coagulation in the lung. Role of caspase-11 in host defense during Klebsiella pneumoniae-evoked pneumonia and sepsis, overview Mus musculus