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Literature summary for 3.4.22.64 extracted from
- Differential roles of caspase-1 and caspase-11 in infection and inflammation (2017), Sci. Rep., 7, 45126 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P70343 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | caspase-1 and caspase-11 display differential roles in response to infection with the fungal pathogen Aspergillus fumigatus. Casp11-/- mice are more susceptible to infection with Aspergillus fumigatus conidia compared with wild-type mice. Casp11-/- mice succumb to infection with a delayed kinetic compared with Casp1Null mice or Casp1-/- Casp11-/- mice. Caspase-11 has no role in the activation of the inflammasome in bone marrow-derived dendritic cells in response to A. fumigatus, but contributes to the host defense against A. fumigatus infection in vivo | Mus musculus |
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