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Literature summary for 3.4.22.64 extracted from

  • Aglietti, R.A.; Estevez, A.; Gupta, A.; Ramirez, M.G.; Liu, P.S.; Kayagaki, N.; Ciferri, C.; Dixit, V.M.; Dueber, E.C.
    GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes (2016), Proc. Natl. Acad. Sci. USA, 113, 7858-7863 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Homo sapiens
-
 gasdermin fragment p30 + gasdermin fragment p20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
-
 Homo sapiens gasdermin fragment p30 + gasdermin fragment p20
-
 ?

General Information

General Information Comment Organism
physiological function gasdermin D fragment p30 that is liberated by caspase-11 forms pores in cellular membrane. p30 is only detected in the membrane-containing fraction of immortalized macrophages after caspase-11 activation by lipopolysaccharides Homo sapiens