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Literature summary for 3.4.22.64 extracted from

  • Kayagaki, N.; Stowe, I.B.; Lee, B.L.; ORourke, K.; Anderson, K.; Warming, S.; Cuellar, T.; Haley, B.; Roose-Girma, M.; Phung, Q.T.; Liu, P.S.; Lill, J.R.; Li, H.; Wu, J.; Kummerfeld, S.; Zhang, J.; Lee, W.P.; Snipas, S.J.; Salvesen, G.S.; Morris, L.X.; Fitzgerald, L.; Zhang, Y.; Bertram, E.M.; Goodnow, C.C.; Di, D.i.x.
    Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling (2015), Nature, 526, 666-671 .
    View publication on PubMed
Search for more literature for 3.4.22.64

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gasdermin D + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70343
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gasdermin D + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CASP4
-
 Mus musculus
caspase-11
-
 Mus musculus

General Information

General Information Comment Organism
physiological function caspase-11 cleaves gasdermin D, and the resulting amino-terminal fragment promotes both pyroptosis and NLRP3-dependent activation of caspase-1 in a cell-intrinsic manner. Gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation. Macrophages from gasdermin-/- mice exhibit defective pyroptosis and interleukin-1beta secretion induced by cytoplasmic lipopolysaccharide or Gram-negative bacteria. Gasdermin-/- mice are protected from a lethal dose of lipopolysaccharide Mus musculus