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Literature summary for 3.4.22.64 extracted from

  • Huang, W.; Xie, W.B.; Qiao, D.; Qiu, P.; Huang, E.; Li, B.; Chen, C.; Liu, C.; Wang, Q.; Lin, Z.; Wang, H.
    Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis (2015), Toxicol. Sci., 145, 68-79.
    View publication on PubMed
Search for more literature for 3.4.22.64

Protein Variants

Protein Variants Comment Organism
additional information enzyme downregulation by siRNA and shRNA sequence targeting caspase-11 Rattus norvegicus
additional information enzyme downregulation by siRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
wedelolactone a specific inhibitor of caspase-11 Homo sapiens
wedelolactone a specific inhibitor of caspase-11 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague Dawley
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme requires activation through proteolytic cleavage Rattus norvegicus
proteolytic modification the enzyme requires activation through proteolytic cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
midbrain
-
 Rattus norvegicus
-
neuron dopaminergic Rattus norvegicus
-
neuron dopaminergic Homo sapiens
-
PC-12 cell
-
 Rattus norvegicus
-
SH-SY5Y cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
malfunction inhibition of caspase-11 expression with either wedelolactone or siRNAs reduces the number of methamphetamine-induced apoptotic cells, silencing of caspase-11 protects PC-12 cells from methamphetamine-induced apoptosis. In addition, blocking caspase-11 expression inhibits methamphetamine-induced activation of caspase-3 and PARP in vitro and in vivo Rattus norvegicus
malfunction inhibition of caspase-11 expression with either wedelolactone or siRNAs reduces the number of methamphetamine-induced apoptotic cells. In addition, blocking caspase-11 expression inhibits methamphetamine-induced activation of caspase-3 and PARP in vitro and in vivo Homo sapiens
physiological function caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis, the caspase-11/caspase-3 signal pathway is involved in methamphetamine-induced neurotoxicity Rattus norvegicus
physiological function caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis, the caspase-11/caspase-3 signal pathway is involved in methamphetamine-induced neurotoxicity Homo sapiens