Literature summary for 3.4.22.64 extracted from

Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene (2009), Arch. Toxicol., 83, 795-803.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	benzene, increase of caspase-4 expression after 12 days of oral benzene treatment to p53KO mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL, wild type and p53KO mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Mus musculus	-
peripheral blood	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
caspase-11	cf 3.4.22.57	Mus musculus

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Release 2026.1 (March 2026)