Cloned (Comment) | Organism |
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gene CASP10, recombinant expression of human caspase-10 in Saccharomyces cerevisiae strain strain BY4741 and derivatives, phenotypes, overview. Identification of 46 suppressors whose coexpression abolishes caspase-10 function and leads to cell curvaival and growth | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
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General Information | Comment | Organism |
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additional information | autophagy is associated to human caspase-10-induced cell death in yeast, a specific process that depends on an intact MAPK pathway, the Factor-arrest (Far) protein family, and the autophagy machinery, overview. Far11 coordinates a death-promoting signal and regulates both autophagy and the DNA damage response. The expression of human caspase-10 in Saccharomyces cerevisiae activates an intracellular death signal that depends on the Far protein complex. Expression of initiator caspase-10 is toxic in yeast and induces a lethal phenotype with most of the principal hallmarks of apoptosis and autophagy, which include the production of ROS, chromatin condensation, phosphatidylserine externalization, and increased vacuolization. The MAP kinases Fus3, Kss1, and Slt2 are activated after the expression of caspase-10 in yeast cells | Homo sapiens |