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Literature summary for 3.4.22.63 extracted from

  • Ng P.W.; Porter A.G.; Janicke R.U.
    Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10 (1999), J. Biol. Chem., 274, 10301-10308.
    View publication on PubMed
Search for more literature for 3.4.22.63

Cloned(Commentary)

Cloned (Comment) Organism
cloning of caspase-10/c and caspase-10/d isoforms Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
perinuclear space caspase-10/c is insoluble and localizes to filamentous perinuclear structures Homo sapiens
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soluble caspase-10/a and caspase-10/d are soluble proteins Homo sapiens
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, caspase-10/c, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92851
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-10/c and caspase-10/d are splice isoforms. Caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase. Caspase-10/d is a hybrid of caspase-10/a (Mch4) and caspase-10/b (FLICE2), as it is identical to FLICE2 except for the small p12 catalytic subunit, which is identical to Mch4 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney fetal, activity is undetectable in the adult Homo sapiens
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lung fetal, activity is undetectable in the adult Homo sapiens
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additional information the expression levels of caspase-10-related mRNAs are generally higher in fetal than in adult tissues Homo sapiens
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skeletal muscle fetal, activity is undetectable in the adult Homo sapiens
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spleen
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 Homo sapiens
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thymus
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development Homo sapiens ?
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 ?

Subunits

Subunits Comment Organism
? x * 40000, caspase-10/c, SDS-PAGE Homo sapiens