Literature summary for 3.4.22.63 extracted from

Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors (1998), J. Biol. Chem., 273, 32608-32613.

Search for more literature for 3.4.22.63

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-AEVD-aldehyde	-	Homo sapiens
acetyl-DEVD-aldehyde	-	Homo sapiens
acetyl-IETD-aldehyde	-	Homo sapiens
acetyl-WEHD-aldehyde	-	Homo sapiens
acetyl-YVAD-aldehyde	-	Homo sapiens
cowpox serpin CrmA	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000012	-	acetyl-DEVD-aldehyde	pH 7.5, 25°C	Homo sapiens
0.000017	-	cowpox serpin CrmA	pH 7.5	Homo sapiens
0.000027	-	acetyl-IETD-aldehyde	pH 7.5, 25°C	Homo sapiens
0.00032	-	acetyl-AEVD-aldehyde	pH 7.5, 25°C	Homo sapiens
0.00033	-	acetyl-WEHD-aldehyde	pH 7.5, 25°C	Homo sapiens
0.000408	-	acetyl-YVAD-aldehyde	pH 7.5, 25°C	Homo sapiens

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Release 2023.1 (January 2023)