Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation dynamics of caspase 9 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-IETD-fluoromethylketone | a caspase-8 specific inhibitor, delays the activation of caspase-3 and caspase-9 significantly | Homo sapiens | |
Z-LEHD-fluoromethylketone | a caspase-9 specific inhibitor, inhibits caspase-9 activation completely | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-9 cleaves the the LEHD sequence | Homo sapiens | ? | - |
? | |
N-acetyl-LEHD-4-trifluoromethylcoumarin 7-amide + H2O | - |
Homo sapiens | N-acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase 9 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | during H2O2-induced apoptosis, caspase 3 is activated directly through caspase 8 and not through the mitochondria-dependent caspase 9 activation | Homo sapiens |