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Literature summary for 3.4.22.62 extracted from

  • Wu, Y.; Wang, D.; Wang, X.; Wang, Y.; Ren, F.; Chang, D.; Chang, Z.; Jia, B.
    Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells (2011), Cell. Physiol. Biochem., 27, 539-546.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activation dynamics of caspase 9 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-IETD-fluoromethylketone a caspase-8 specific inhibitor, delays the activation of caspase-3 and caspase-9 significantly Homo sapiens
Z-LEHD-fluoromethylketone a caspase-9 specific inhibitor, inhibits caspase-9 activation completely Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-9 cleaves the the LEHD sequence Homo sapiens ?
-
?
N-acetyl-LEHD-4-trifluoromethylcoumarin 7-amide + H2O
-
Homo sapiens N-acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin
-
?

Synonyms

Synonyms Comment Organism
caspase 9
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
additional information during H2O2-induced apoptosis, caspase 3 is activated directly through caspase 8 and not through the mitochondria-dependent caspase 9 activation Homo sapiens