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Literature summary for 3.4.22.62 extracted from

  • Gyrd-Hansen, M.; Farkas, T.; Fehrenbacher, N.; Bastholm, L.; Hoyer-Hansen, M.; Elling, F.; Wallach, D.; Flavell, R.; Kroemer, G.; Nylandsted, J.; Jaeaettelae, M.
    Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9 (2006), Mol. Cell. Biol., 26, 7880-7891.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-8-cleaved caspase-9 induces lysosomal membrane permeabilization but fails to activate the effector caspases whereas apoptosome-dependent activation of caspase-9 can trigger both events. Caspase-9 plays a dual role in cell death signaling, as an activator of effector caspases and lysosomal membrane permeabilization ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8-cleaved caspase-9 induces lysosomal membrane permeabilization but fails to activate the effector caspases whereas apoptosome-dependent activation of caspase-9 can trigger both events. Caspase-9 plays a dual role in cell death signaling, as an activator of effector caspases and lysosomal membrane permeabilization Mus musculus ?
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