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Literature summary for 3.4.22.62 extracted from

  • Lemaire, C.; Godefroy, N.; Costina-Parvu, I.; Rincheval, V.; Renaud, F.; Trotot, P.; Bouleau, S.; Mignotte, B.; Vayssiere, J.L.
    Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb (2005), Oncogene, 24, 3297-3308.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinoblastoma protein Rb + H2O Rattus norvegicus caspase-9 interferes, upstream of the mitochondrion, with P53-induced apoptosis in both immortalized and primary fibroblasts. The involvement of caspase-9 in a premitochondrial protective pathway results from the cleavage of retinoblastoma protein Rb (tumor suppressor), at a LExD site, into a p76Rb form, which antagonizes p53-induced apoptosis p76Rb + ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinoblastoma protein Rb + H2O caspase-9 interferes, upstream of the mitochondrion, with P53-induced apoptosis in both immortalized and primary fibroblasts. The involvement of caspase-9 in a premitochondrial protective pathway results from the cleavage of retinoblastoma protein Rb (tumor suppressor), at a LExD site, into a p76Rb form, which antagonizes p53-induced apoptosis Rattus norvegicus p76Rb + ?
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