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Literature summary for 3.4.22.62 extracted from

  • Johnson, C.R.; Jarvis, W.D.
    Caspase-9 regulation: an update (2004), Apoptosis, 9, 423-427.
    View publication on PubMed
Search for more literature for 3.4.22.62

Cloned(Commentary)

Cloned (Comment) Organism
caspase-9S is cloned from human liver cDNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
nitrosylation nitrosylation of caspase-9 at C163 is dependent, at least in part, on subcellular localization. 68% of the procaspase-9 in mitochondria is nitrosylated and 11% of the procaspase-9 in the cytoplasm in unstimulated 10C9 human B cells Homo sapiens
phosphoprotein the kinases PKB-Akt and ERK2 are involved in the phosphorylation of human caspase-9 at Ser196 and Thr125, respectively Homo sapiens
proteolytic modification proteolytic processing is associated with the removal of a leader sequence, processing by caspase-3 at amino acid 130 and 330. Autolytic processing at amino acid 307 and 315 Homo sapiens
proteolytic modification proteolytic processing is associiated with the removal of a leader sequence, processing by caspase-3 at amino acid 130 and 330. Autolytic processing at amino acid 307 and 315 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-cell 10C9 Homo sapiens
-
B-lymphocyte 10C9 Homo sapiens
-
liver
-
 Homo sapiens
-